Forskning och utveckling

Unilabs strävar efter att främja forskning och utveckling (FoU) inom diagnostik och patientnära forskning för att stödja såväl Unilabs utveckling såsom våra kunders verksamheter på bästa sätt.

Som ett led i Unilabs strävan att satsa på utveckling finns särskilda medel avsatta för dessa aktiviteter. Medel tilldelas enskilda individer eller grupper som arbetar med utveckling och test av nya teknologier/metoder, projekt som utvecklar kompetens i företaget eller patientnära forskning med syftet att förvärva forskningskompetens eller kunskap inom områden som berör vår och/eller våra kunders verksamhet. Patientnära forskning och projekt i samverkan med våra kunder är något vi gärna stödjer.

Majoriteten av medicinska beslut baseras på laboratoriesvar och de flesta forskningsprojekt har laboratorieanalyser som en viktig del. Sjukvårdens verksamhetsprocesser utvecklas på många plan och mobiliserar många utvecklingsmetoder såsom Lean, Sex Sigma i kombination med ISO-reglererat kvalitetssystem.

Ett område som för närvarande har en explosionsartad utveckling är klinisk molekylärbiologi. Vi förfogar över mycket god kompetens på området och moderna automatiserade tekniska plattformar. Humangenetikens betydelse vid ett stort antal sjukdomstillstånd såsom exempelvis cancer, infektions- och folksjukdomar blir alltmer tydlig. Detta skapar helt nya möjligheter för laboratorier att bidra i vårdens processer och skapa nytt värde för patienten.  

Scientific publications, corporate homepage>>>

Scientific corner, corporate homepage>>>


Publikationer med medverkan från Unilabs medarbetare i Norden

2010

Strand L, Jenkins A, Grude N, Allum A-G, Mykland H-C, Nowrouzian FL, Kristiansen B-E.
Emergence of fluoroquinolone-resistant clonal group A: clonal analysis of Norwegian and Russian E. coli isolates.

APMIS 2010. In press.

Abstract

Öfverholm A, Arkblad E, Skrtic S, Albertsson P, Shubbar E, Enerbäck C.
Two cases of 5-fluorouracil toxicity linked with gene variants in the DPYD gene.

 Clin Biochem 2010 Feb;43(3):331-334.

Abstract

 

2009

Stark L, Matussek A, Strindhall J, Geffers R, Buer J, Kihlström E, Monnecke S, Löfgren S, Lindgren PE.
Staphylococcus aureus isolates from blood and anterior nares induce similar innate immune responses in endothelial cells.

APMIS 2009 Nov;117(11):814-824

Abstract

 

Henningsson AJ, Malmvall BE, Ernerudh J, Matussek A, Forsberg P.
Neuroborreliosis - an epidemiological, clinical and health economical study from an endemic area in the south-east of Sweden.

Clin Microbiol Infect 2009 Sept 29

Abstract

 

Skaare D, Allum AG, Anthonisen IL, Jenkins A, Lia A, Strand L, Tveten Y, Kristiansen BE.
Mutant ftsl genes in the emergence of PBP-mediated beta-lactam resistance in Haemophilus influenzae in Norway.

Clin Microbiol Infect 2009 Sep 8.

Abstract

 

Börjesson S, Matussek A, Melin S, Löfgren S, Lindgren PE.
Methicillin-resistant Staphylococcus aureus (MRSA) in municipal wastewater: an uncharted threat?

J Appl Microbiol 2009 Aug 6.

Abstract

 

Rosef O, Paulauskas A, Grude N, Haslekås C, Jenkins A.
Comparison of Norwegian poultry, waterborne and clinical isolates of Campylobacter jejuni by ribotyping.

J Bacteriol Res 2009;1(5):51-57

Abstract

 

Gustafsson E, Jacobsson G, Nilsson P, Enroth H, Beronius MK, Andersson R, Arvidson S.
Invasive Staphylococcus aureus strains are highly variable in PFGE patterns, agr group and exoprotein production.

Scand J Infect Dis 2009 Jun 9:1-7

Abstract

 

Melin S, Haeggman S, Olsson-Liljequist B, Sjolund M, Nilsson PA, Isaksson B, Lofgren S, Matussek A.
Epidemiological typing of methicillin-resistant Staphylococcus aureus (MRSA): spa typing versus pulsed-field gel electrophoresis.

Scand J Infect Dis 2009 May 8:1-7

Abstract

 

Borjesson S, Dienues O, Jarnheimer PA, Olsen B, Matussek A, Lindgren PE.
Quantification of genes encoding resistance to aminoglycosides, beta-lactams and tetracyclines in wastewater environments by real-time PCR.

Int J Environ Health Res 2009 Apr 2:1-12

Abstract

 

Dicksved J, Lindberg M, Rosenquist M, Enroth H, Jansson JK, Engstrand L.
Molecular characterization of the stomach microbiota in patients with gastric cancer and in controls.

J Med Microbiol 2009 Apr;58(Pt 4):509-516

Abstract

 

Rodhe N, Lofgren S, Strindhall J, Matussek A, Molstad S.
Cytokines in urine in elderly subjects with acute cystitis and asymptomatic bacteriuria.

Scand J Prim Health Care 2009 Feb 26:1-6

Abstract

 

Nordgren J, Matussek A, Mattsson A, Svensson L, Lingren PE.
Prevalence of Norovirus and factors influencing virus concentrations during one-year in full-scale wastewater treatment plant.

Water Res 2009 Mar;43(4):1117-25

Abstract

 

Arkblad E, Tulinius M, Kroksmark AK, Henricsson M, Darin N.
A population-based study of genotypic and phenotypic variability in children with spinal muscular atrophy.

Acta Paediatr 2009;May;98(5):865-872

Abstract

 

B-E Kristiansen, P Brandtzæg, B Bjorvatn, CO Solberg.
Meningokockvaccineförsöket 1988-1991.

Tidskr Nor Legeforen nr 3 2009, 129:192-194

Abstract

 

S Börjesson, S Melin, A Matussek, P-E Lindgren
A seasonal study of the mecA gene and Staphylococcus aureus including methicillin-resistant S. aureus in a municipal wastewater treatment plant.

 

Water Research 2009 Mar:43(4):925-32

Abstract

 

Persson C, Engstrand L, Nyrén O, Hansson LE, Enroth H, Ekström AM, Ye W.
Interleukin 1-beta gene polymorphisms and risk of gastric cancer in Sweden.

Scand J Gastroenterol 2009;44(3):339-345

Abstract

 

2008

Enroth H, Engstrand L.
Helicobacter pylori. In International Encyclopedia of Public Health, First edition, Elsevier, SanDiego Academic Press. 2008, volume 3, pp. 290-294



Link ,Preview

 

Rodhe N, Lofgren S, Matussek A, Andre M, Englund L, Kuhn I, Molstad S.
Asymptomatic bacteriuria in the elderly: High prevalence and high turnover of strains.

Scand J Infect Dis 2008;40(10):804-10

Abstract

 

Blatny JM, Reif BA, Skogan G, Andreassen O, Hoiby EA, Ask E, Waagen V, Aanonsen D, Aaberge IS, Caugant DA.
Tracking airborne Legionella and Legionella pneumophila at a biological treatment plant.

Environ Sci Technol 2008 Oct 1;42(19):7360-7367

Abstract

 

Grude N, Strand L, Mykland H, Nowrouzian FL, Nyhus J, Jenkins A, Kristiansen BE.
Fluoroquinolone-resistant uropathogenic Escherichia coli in Norway: evidence of clonal spread.

Clin Microbiol Infect 2008 May;14(5):498-500

Abstract

 

Gustafsson C, Mjösberg J, Matussek A, Geffers R, Matthiesen L, Berg G, Sharma S, Buer J, Ernerudh J.
Gene expression profiling of human decidual macrophages: evidence for immunosuppressive phenotype.

PLoS ONE 2008 Apr 30;3(4):e2078

Abstract

Seifert O, Bayat A, Geffers R, Dienus K, Buer J, Löfgren S, Matussek A.
Identification of unique gene expression patterns within different lesional sites of keloids.

 

 

Wound Repair Regen 2008 Mar-Apr;16(2):254-65

Abstract

 

Olesen BT, Clausen J, Vang O
Characterization of the transcriptional profile in primary astrocytes after oxidative stress induced by Paraquat.

Neurotoxicology 2008; 29(1):13-21

Abstract

 

2007

Strömberg C, Johansson G, Adolfsson A
Acute abdominal pain: diagnostic impact of immediate CT  scanning.

World J Surgery 2007; 31(12): 2347-2354, discussion 2355-8

Abstract

 

Lindequist S, Morelli C
Modern imaging of the hand, wrist, and forearm.

J Hand Ther 2007; 20(2):119-30, quiz 131 (Review)

Abstract

 

Bergman A, Fernandez V, Holmström KO, Claesson BE, Enroth H
Rapid identification of pathogenic yeast isolates by real-time PCR and two-dimensional melting-point analysis.

Eur J Clin Microbiol Infect Dis. 2007; 26(11):813-8

Abstract

 

Hugosson A, Hjorth M, Bernander S, Claesson BE, Johansson A, Larsson H, Nolskog P, Pap J, Svensson N, Ulleryd P
A community outbreak of Legionnaires' disease from an industrial cooling tower: assessment of clinical features and diagnostic procedures.

Scand J Infect Dis. 2007; 39(3):217-24

Abstract

 

Backhaus E, Berg S, Trollfors B, Andersson R, Persson E, Claesson BE, Larsson P, Ek E, Jonsson L, Rådberg G, Johansson S, Ripa T, Karlsson D, Andersson K
Antimicrobial susceptibility of invasive pneumococcal isolates from a region in south-west Sweden 1998-2001.

Scand J Infect Dis. 2007; 39(1):19-27

Abstract

 

Fendukly F, Bernander S, Hanson HS
Nosocomial Legionnaires' disease caused by Legionella pneumophila serogroup 6: implication of the sequence-based typing method (SBT).

Scand J Infect Dis. 2007; 39(3):213-6

Abstract

 

Wedborg M, Persson T, Larsson T
On the distribution of UV-blue fluorescent organic matter in the Southern Ocean.

Deep-Sea Research I; 2007; 54, 1957-1971

Abstract

 

Törnhage CJ, Burian P, Bergström T
Fatal intrauterine infection by herpes simplex vitus type 2 in an infant from a mother lacking seroactivity to glycoprotein G.

Scand J of Inf Diseases 2007; 39:449-453

Abstract

 

Ung KA, Ljung A, Wågermark J, Lindholm J, Rydberg L, Kilander A, Stotzer PO, Burian P
Brush cytology is superior to biopsies obtained by a new device in bile duct structures.

Hepato-Gastroenterology 2007; 54;664-668

Abstract

 

 

Bokström H, Holst RM, Mattsson LA, Fyhr IM
Congenital cytomegalovirus infection presenting with echogenic bowel and oligohydramnios.

Acta Obstet Gynecol Scand. 2007; 86(2):248-50

Abstract

 

Hansson J, Bergenmar M, Hofer PA, Lundell G, Månsson-Brahme E, Ringborg U, Synnerstad I, Ternesten-Bratel A, Wennberg AM, Rosdahl I
Monitoring of kindreds with hereditary predisposition for cutaneous melanoma and dysplastic nevus syndrome is worthwhile – results of a Swedish preventive program.

Journal of Clinical Oncology 2007; 25(19):2819-2824

Abstract

 

 

2006

Fahrenkrug J, Georg B, Hannibal J, Hindersson P, Gras S 
Diurnal rhythmicity of the clock genes Per1 and Per2 in the rat ovary.

Endocrinology. 2006; 147(8):3769-76

Article

 

Dyerberg J, Stender S, Astrup A
Fish is still healthy.

BMJ 2006. Rapid responses to "Risks and benefits of omga 3 fats for  mortality,   cardiovascular disease, and cancer: systematic review"

Article

 

Stender S, Dyerberg J
Kosthold og helse.

Michael 2006; 3:Suppl 3:54-63

Article (Norvegian)

 

Stender S, Astrup A, Dyerberg J
High Levels of Industrially Produced Trans Fat in Popular Fast Foods.

N Engl J Med 2006; 354:1650-2

Abstract

 

Stender S, Dyerberg J, Bysted A, Leth T, Astrup A
Højt indhold af industrielt producerede transfedtsyrer I populære fødevarer – men ikke i Danmark – sekundærpublikation.

Ugeskr Læger 2006; 168:1654-7

Article (Danish)

 

Jakobsen MU, Bysted A, Andersen NL, Heitmann BL, Hartkopp HB, Leth T, Overvad K,
Dyerberg J
Intake of ruminant trans fatty acids and risk of coronary heart disease-An overwiev.

Atherosclerosis Supplements 2006; 7:9-11

Abstract

 

Dyerberg J, Christensen JH, Eskesen D, Astrup A, Stender S
Trans, and n-3 polyunsaturated fatty acids and vascular function-A yin yang situation?

Atherosclerosis Supplements 2006; 7:33-35

Abstract

 

Stender S, Dyerberg J, Bysted A, Leth T, Astrup A
A trans world journey.

Atherosclerosis Supplements 2006; 7:47-52

Abstract

 

Skibsted LH, Dragsted LO, Dyerberg J, Hansen HS, Kiens B, Ovesen L, Tjønneland A
Antioxidanter og helbred.

Ugeskr Læger  2006; 168:2787-9

Article (Danish)

 

Berg S, Trollfors B, Persson E, Backhaus E, Larsson P, Ek E, Claesson BE, Jonsson L, Rådberg G, Johansson S, Ripa T, Kaltoft MS, Konradsen HB
Serotypes of Streptococcus pneumoniae isolated from blood and cerebrospinal fluid related to vaccine serotypes and to clinical characteristics.

Scand J Infect Dis. 2006; 38(6-7):427-32

Abstract

 

Karlsson L, Lindroth K, Elowson S, Persson A, Eriksson M, Midtvedt AC, van Raalte M, Schewenius M, Ulleryd P
[Hygiene risk factors and antibiotics use. A point-prevalence study in long-term municipality care in the county of western Gotaland]

Lakartidningen. 2006; 11-17;103(41):3080-3

 

Drogset JO, Grontvedt T, Myhr G
Magnetic resonance imaging analysis of bioabsorbable interference screws used for fixation of bone-patellar tendon-bone autografts in endoscopic reconstruction of the anterior cruciate ligament.

Am J Sports Med. 2006; 34(7):1164-9

Abstract

 

Bathen TF, Sjobakk TE, Skranes J, Brubakk AM, Vik T, Martinussen M, Myhr GE, Gribbestad IS, Axelson D
Cerebral metabolite differences in adolescents with low birth weight: assessment with in vivo proton MR spectroscopy.

Pediatr Radiol. 2006; 36(8):802-9

Abstract

 

Lindbäck E, Islam S, Unemo M, Wretlind B
Transformation of ciprofloxacin-resistant Neisseria gonorrhoeae gyrA, pare and porB1b genes.

Int J Antimicrob Agents 2006; 28(3):206-11

Article

 

Lindbäck E, Unemo M, Akhras M, Gharizadeh B, Fredlund H, Pourmand N, Wretlind B Pyrosequencing of the DNA gyrase gene in Neisseria gonorrhoeae: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.

APMIS, 2006; 114(12):837-41

Abstract

 

Källman O, Lundberg C , Wretlind B, Örtqvist Å
Gram-negative bacteria from patients seeking medical advice in Stockholm after the tsunami catastrophe.

Scand J Infect Dis. 2006; 38(6-7):448-50

Abstract

 

Lindelof B, Jarnvik J, Ternesten-Bratel A, Granath F, Hedblad MA
Mortality and clinicopathological features of cutaneous squamous cell carcinoma in organ transplant recipients: a study of the Swedish cohort.

Acta Derm Venereol 2006; 86, 219-22

Article

 

Paoli J, Ternesten-Bratel A, Lowhagen GB, Stenquist B, Forslund O, Wennberg AM
Penile intraepithelial neoplasia: results of photodynamic therapy.

Acta Derm Venerol 2006; 86, 418-21 

Article

 


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